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A series of 1,6-dihydro-2-hydroxyethylamino-6-oxo-4-arylpyrimidine-5-carbonitriles 8a-i, and 4-amino-2-hydroxyethylamino-6-arylpyrimidine-5-carbonitriles 9a-i were prepared. Multicomponent reaction of araaldehyde 1a-i , S-methylisothiourea sulfate 2 with ethyl cyanoacetate 3 afforded 1,6-dihydro-2-methylthio-6-oxo-4-arylpyrimidine-5-carbonitriles 4a-i. Also, multicomponent reaction of 1, 2 with malononitrile 5 afforded 4-amino-2-methylthio-6-arylpyrimidine-5-carbonitriles 6a-i. Reaction of compounds 4a-i, and 6a-i with ethanolamine 7 under solvent free condition at 130-140 °C afforded 8a-i, and 9a-i respectively. The purity of the new compounds was checked by TLC and elucidation of their structures was confirmed by IR, 1H-NMR, 13C-NMR and HRMS spectrometry. Compounds were subjected to NCI in vitro assessment for their anticancer activity at a single dose of 10 μM of test compounds, Also, all of the tested compounds were in vitro assessment for their antibacterial and antifungal activities in a comparison to chloramphenicol and clotrimazole as reference antibacterial and antifungal drugs respectively. All the tested compounds showed varied anticancer activities ranging from weak to moderate activities. In the other

Design and synthesis of newly substituted 2-(2-Hydroxyethylamino)pyrimidine-5-carbonitrile with potential anticancer and antimicrobial activities