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Background: PARP-1 overexpression has been identified in several malignancies. Few studies have handled the expression of PARP-1 protein in gastric carcinoma and its associations with outcome. Aim of Study: This study aimed at exploring the significance of PARP-1 expression in gastric adenocarcinoma and correlation with HER2 status. Subjects and Methods: Quantitative expression of PARP1 proteins was assayed by Immunohistochemistry in 40 cases of gastric adenocarcinoma. PARP-1 mRNA was moreover evaluated by Quantitative Real-Time Polymerase Chain Reaction. Results: The level of expression of mRNA expression level was significantly increased in 25 of 40 (62.5%) of gastric adenocarcinoma tissues compared with the corresponding adjacent non cancer tissues (p<0.001). Positive expression of PARP-1 protein was detected in 23/40 (57.5%) of gastric adenocarcinoma. PARP-1 expression in cancer tissues was significantly higher than adjacent non-cancerous tissue (p<0.001). The aberrant high expression of PARP-1 showed significant correlation with depth of invasion ( p<0.001), advanced stage (p<0.001), nodal (p<0.05) and distant metastasis (p<0.001). Positive correlation was detected between PARP-1 and positive HER2 status (p<0.001). Conclusion: PARP-1 level is up regulated significantly in gastric adenocarcinoma tissue. PARP-1 is positively correlated with positive HER2 status and poor prognostic factors. PARP-1 might be potential prognostic marker for gastric adenocarcinoma.

Evaluation of (PARP-1) Expression in Gastric Carcinoma by Immunohistochemistry and Quantitative Real-Time PCR and its Relation to HER2 Status