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Rheumatoid arthritis (RA) is a disease characterized by destruction of joint structures such as articular cartilage and bone. The pathogenic mechanisms responsible for tissue destruction are not well understood. The aim of the present study was to measure the serum concentrations of specific cartilage and bone molecules reflecting tissue turnover to investigate disease activity. The study included 30 rheumatoid arthritis (RA) patients with age range 42 – 66 years, sixteen patients were rapid erosive patients and fourteen were slow erosive, compared with 20 matched normal population with age range 40 – 63 years. All studied individuals were subjected to full history taking clinical examination and laboratory investigations including measurement of serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), high sensitive Creactive protein (CRP), erythrocyte sedimentation rate (ESR) and RF concentration, measurement of activity of RA by disease activity score ( DAS) 28 joint counts. The study showed a significantly higher values of COMP, HA, CRP and ESR in slow erosive (P < 0.001) and rapid erosive (P <0.0001) RA patients when compared to controls. There were significantly higher values of COMP, HA, CRP and ESR in rapid erosive RA patients compared to slow erosive RA patients. A significant positive correlation between serum levels of COMP and HA and age, disease duration, Larsen score, DAS and CRP and ESR was found. Also, there was a significant positive correlation between serum levels of COMP and HA (r = 0.674, P <0.01). It could be concluded that the measurement of some serological biomarkers that reflect bone and cartilage destruction in RA patients, could be used to investigate disease activity and increase the knowledge of the basic pathophysiology of joint disease.

Serum Levels of Hyaluronic Acid (HA) and Cartilage Oligomeric Matrix Protein (COMP). Predictors of Disease Progression in Rheumatoid Arthritis