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The present work was performed to investigate the effect of acute and chronic stress of pain and ethanol on the reproductive function, hormonal response and β endorphin release in non pregnant, and pregnant female albino rats and their offspring. This study was performed on 60 mature female albino rats divided into two groups, non pregnant group and pregnant group, each group is subdivided into 3 groups: 1Control group 2Acute stress group in which the rats were exposed to stress of pain for one hour or ethanol injection 3-Chronic group in which the rats were exposed to stress of pain for one hour or ethanol injection daily for one week. The pregnant group was subdivided in the same manner into three groups, and the resulted neonates were divided according their mothers into three groups. At the end of experiment, the normal rats and neonates of pregnant rats were decapitated, and blood samples were collected. The pregnant rat's blood was collected from retro orbital plexus. Then serum was separated and used for determination of serum progesterone, estrogen, follicle stimulating hormone (FSH), Luteinizing hormone (LH), serotonin and β endorphin levels. Tissue samples were taken from normal group by opening of the abdominal cavity. Ovaries, ovarian ducts and uterus were excised for histological examination. The results revealed significant increase in progesterone, estrogen, LH, FSH and serotonin, and significant reduction in β endorphin levels in acute non pregnant and pregnant groups. The chronic pregnant and non pregnant groups showed, significant reduction in progesterone, estrogen and LH and significant increase in FSH, serotonin and β endorphin levels.. β endorphin of neonates showed significant reduction in neonates of rats exposed to chronic ethanol injection and significant increase in neonates of rats exposed to chronic pain. Histological examination showed reduction of uterine vascularity, leucocytes infiltration, in rats exposed to acute stress of pain and ethanol injection. The chronic groups showed dilated uterine lumen, increased uterine vascularity, leucocytes infiltration and increased viable corpora lutea. It is concluded that the application of stress of pain or injection of ethanol to female albino rats caused disturbance of reproductive function. Also, ethanol injection to pregnant rats caused suppression in β endorphin release in their offspring,, which may be due to apoptotic death of neurons secreting β endorphin. Bull. Egypt. Soc. Physiol. Sci. 28 (2) 2008 El-Sherbeny et al.

bulletin of egyptian society for physiological sciences

A Study on the Effects of Stress of Pain and Ethanol on the Reproductive Function and Beta-endorphin Release in Mature Female Albino Rats and Their Offspring