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Objectives: The main purpose of this work is to design a simple, sensitive, accurate and precise potentiometric membrane ion selective electrodes for selective determination of loperamide hydrochloride in bulk powder and in pharmaceutical preparation. Methods: Electrochemical behavior of loperamide hydrochloride were investigated using PVC membrane and modified carbon nanotubes paste sensors. The linearity of this developed method was established in the concentration range of 10-5 - 10-2 M and10-6 - 10-2 M shows a Nernstian slope of 57.38 mV and  58.74 mV for  PVC  and  Carbon paste sensor,  respectively. Results: Validation parameters such as specificity, linearity, accuracy, precision, stability, limit of detection were found to be within the acceptance limit as studied according  to  IUPAC recommendation data. Conclusion: Both sensors are successfully applied for potentiometric determination of loperamide hydrochloride in its pure form and pharmaceutical formulations.

journal of advanced pharmacy research

Application of PVC Membrane and Modified Carbon Nanotubes Paste as Electrochemical Sensors for Potentiometric Determination of Loperamide Hydrochloride