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Investigators have been searching for alternative remineralizing compounds that have superior properties to thoseconventionally used; in order to reduce the risk of fluorosis in children.OBJECTIVES: To evaluate the anti-caries effect of hexametaphosphate (HMP) combined with low-fluoride toothpaste on primary teethenamel surface using fluoride uptake analysis.MATERIALS AND METHODS: Seventy five freshly extracted anterior primary teeth were sectioned into two halves in a labiolingualdirection (150 specimens). One half of each tooth remained untreated and served as control and the other corresponding half that was treatedwith the remineralizing toothpaste served as test. Specimens were assigned into subgroup IA (untreated) n=25, subgroup IB (250ppm F +0.5% HMP) n=25, subgroup IIA (untreated) n=25, subgroup IIB (500 ppm F) n=25 and subgroup IIIA (untreated) n=25, subgroup IIIB (1000ppm F) n=25. Specimens were subjected to pH cycling for five days and immersed in remineralizing solution for an additional two days. Theenamel fluoride uptake analysis of specimens was evaluated quantitatively using an ion specific electrode. Data were analyzed using MannWhitney U, Kruskal-Wallis and Post-hoc pair-wise test.RESULTS: There was a significant high median enamel fluoride uptake between test subgroups IB (250ppm F + 0.5% HMP),IIIB (1000 ppm F) and their controls where p=0.008 and p=0.008 respectively, while there was no significant difference inmedian enamel fluoride uptake between the test subgroup IIB (500 ppm F) and its control subgroup IIA where p=0.690. Pairwise comparison of enamel fluoride uptake in the three test subgroups IB, IIB and IIIB showed significant high median value ofsubgroup IB than subgroup IIIB where p=0.027.CONCLUSIONS: A toothpaste containing 250ppm F + 0.5% HMP has a high anti-caries potential in comparison to pediatric 500 ppm Fand standard 1000 ppm F toothpastes on primary teeth.KEYWORDS: Demineralization, fluoride, hexametaphosphate, enamel, pH cycling, toothpastes.

REMINERALIZATION EFFECT OF HEXAMET APHOSPHATE COMBINED WITH LOW FLUORIDE TOOTHPASTE ON ENAMEL SURFACE OF PRIMARY TEETH