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We design and describe here a simple route for the synthesis of a new multi heterocycle fused 1,4-oxazinopyranoquinolinones compatible with many functional groups. This method proceeds through various cyclic condensation reactions of (3-amino or 3-nitropyrano)[3,2-c]quinoline2,5(6H)-dione precursors with different 1,2-bifunctional electrophiles. The synthesized compounds are confirmed by infrared (IR), proton (H) and carbon-13 (C) nuclear magnetic resonance (NMR) spectroscopy and electrospray ionization mass spectrometry (ESI-MS).

A Convenient and Efficient Method for the Synthesis of a Novel Series of N‑Butyl‑1,4-oxazino[2’,3’:4,5]pyrano[3,2-c]quinolinones