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Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.

Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε‑caprolactone)-poly(ethylene oxide) and F127®