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The genus Lippia comprises approximately 200 species of herbs, shrubs and small trees,distributed throughout the South and Central America and tropical Africa. The species Lippiagracilis Schauer is an endemic aromatic plant of the Brazilian Northeast normally found in thestates of Bahia, Sergipe and Piaui. The traditional communities of Caatinga, a semi-arid regionof the Brazilian Northeast, use its leaves to treat throat and mouth infections, cutaneous diseases,ulcers, vagina disorders, acne, Pityriasis alba, dandruff, burns, wounds, sinusitis, bronchitis,nasal congestion, headache, jaundice and paralysis. Considering that the main investigations intothe L. gracilis Schauer species are focused on its volatile constituents, in this report, we describethe isolation, by liquid chromatography with diode array detector-solid phase extraction/nuclearmagnetic resonance (LC-DAD-SPE/NMR), of five flavonoids besides free and glycosidicallybound carvacrol from an infusion of the leaves of a genotype of this species.

Secondary Metabolites from an Infusion of Lippia gracilis Schauer Using the LC‑DAD-SPE/NMR Hyphenation Technique