English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Cadmium (Cd) is a toxic heavy metal, particularly in the kidney. Zinc transporters have been reported to be responsible for the absorption of Cd in the kidney. Interestingly, we previously found in a DNA microarray that exposure to Cd suppressed the expression of the gene coding for the zinc transporter ZIP1 (SLC39A1) in HK-2 human kidney proximal tubular cells. In this study, we validated by realtime RT-PCR that SLC39A1 gene expression was indeed decreased upon treatment with 40 μM Cd. We also demonstrated that knockdown of SLC39A1 by siRNA transfection conferred resistance to Cd in HK-2 cells. Together, this suggests that gene suppression of SLC39A1 by Cd is involved in the defense mechanism against the Cd toxicity in HK-2 cells.

Effects of cadmium on the gene expression of <i>SLC39A1 </i>coding for ZIP1 protein