English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Acute organophosphorus (OP) pesticide poisoning is widespread and is the most common poisoning in many developing countries and vary in different geographic regions. Organophosphorus compounds are anti acetylcholinesterase’s which exert their toxicity by interfering with the normal function of acetylcholine. So the present study was done to assess the serum cholinesterase levels correlation with clinical severity to determine the treatment outcome (Need for mechanical ventilation and mortality). Material and methods: A cross-sectional study was conducted among 100 patients admitted with OPC poisoning in the department of general medicine, Velammal Medical College Hospital and Research Institute, Madurai from January 2016 to July 2019. The diagnosis was made based on history or evidence of exposure to OP compound within 24 hours; Clinical severity was assessed and categorized according to POP scale. Serum Cholinesterase values were defined as per Proudfoot classification. IBM SPSS version 22 was used for statistical analysis. Results: OP poisoning predominantly affected males in the age group 21 to 40 years. The majority had a moderate grade of poisoning with Serum cholinesterase levels between 2001 to 5000 (IU/l). In this study, the mortality was 25%, and 40% of patients had to be ventilated. There was no statistically significant relationship between age, gender, clinical severity, time-lapse, Serum cholinesterase levels, mortality with mechanical ventilation. Mortality rate showed a statistically significant relation with clinical severity (p<0.001). Conclusion: Clinical severity was associated with treatment outcomes. No particular trend of the association was observed between clinical severity and serum cholinesterase levels. Serum cholinesterase levels had shown no association with outcomes

international journal of contemporary medical research

Relation of Serum Cholinesterase with Clinical Severity and Treatment Outcomes of Organophosphorus Poisoning in a Tertiary Care Center, a Prospective Observational Study