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To compare between arterial versus venous ammonia levels in correlation with the severity of hepatic encephalopathy and to correlate between ammonia levels and clinical severity of hepatic encephalopathy. Material and methods: After informed consent from the patient or their relatives, 50 patients in hepatic encephalopathy due to advanced liver disease were taken into the study after clinical assessment of their grading of encephalopathy using West Haven Criteria.Arterial and Venous ammonia levels were assessed at the same time during admission using Enzymatic UV method. Results: 88% of the subjects (n=44) were males and 12% of the subjects (n=6) were females. The highest incidence of hepatic encephalopathy was seen in the age group of 50 to 70 years (54%), 30 to 50 years (30%) and >70 years was 16%.While correlating the arterial and venous ammonia levels with clinical grading of hepatic encephalopathy, there was moderate correlation between hepatic encephalopathy and arterial ammonia and venous ammonia levels, however statistically very high significant correlation with an r=0.569 and r=0.504 respectively. Conclusion: Despite significant correlation of arterial and venous ammonia with hepatic encephalopathy neither is more useful than the other for the determination of the severity of hepatic encephalopathy.

Arterial vs Venous Ammonia Levels in Correlation with severity of Hepatic Encephalopathy