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The mode of treatment of APD is changed radically ever since the role of H.pylori is proved for this condition. The study was aimed to detect the utility of anti H.pylori IgG estimation in the diagnosis of acid peptic diseases. Material and methods: Endoscopic examination of stomach followed by Rapid Urease Test on the biopsy material and the anti-Helicobacter pylori IgG quantitative estimation were done in 85 patients with history suggestive of acid peptic disease. Results: 46 (100%) patients with gastritis showed positive Rapid Urease Test within 30 minutes and had serum IgG >30 IU/ml. 10 patients with peptic ulcer, 12 patients with non ulcer dyspepsia and 2 patients with carcinoma stomach gave positive Rapid Urease Test after 30minutes and serum IgG level was < 30 IU/ml for these patients. Of the 70 Rapid Urease Test positive in the study, 2 of the 12 non ulcer dyspepsia patients were negative for antibody. Endoscopy findings in 15 subjects were normal and negative for Rapid Urease Test and antiHelicobacter pylori IgG antibody. Conclusion: Estimation of Serum anti-Helicobacter pylori IgG may be useful as a non invasive method in the diagnosis of gastritis.

Utility of Anti-Helicobacter pylori IgG Estimation in the Diagnosis of Acid Peptic Diseases: A Comparison of Serum IgG Level with Rapid Urease Test