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Minimal alveolar concentration (MAC) of volatile anaesthetics is that which prevent movement in 50% of subjects in response to a noxious stimulus. MAC is influenced by several drugs like fentanyl, midazolam, propofol, clonidine. Various successful studies have been done to demonstrate the effect of IV anaesthetics and opioids on MAC of various inhaled anaesthetics in balanced anaesthesia settings. To assess the effect of a perioperative lidocaine infusion on the MAC of isoflurane in a balanced anaesthesia technique by correlating it with the depth of anaesthesia as assessed by the Bispectral Index (BIS). Material and methods: It is a prospective randomized study consisting of 100 patients. The patients were categorized into group L and group S, Group L received a bolus of 1.5mg/ kg of lidocaine five minutes before the induction of general anaesthesia followed by 1.5mg/kg/hr of lidocaine infusion till the end of the surgical procedure or upto a maximum of three hours (whichever was earlier). Group S received saline similarly. BIS was maintained between 40 to 60 and MAC of isoflurane was measured in both group. Result: Significant difference with regard to MAC of isoflurane used to maintain anaesthesia was noted between the two groups. It was found overall average MAC of isoflurane in Group L was (0.761±0.011) and control group was (0.885±0.020). Conclusion: Our study found that lidocaine loading dose followed by infusion significantly reduces volatile anaesthetic requirement as measured by MAC of isoflurane

international journal of contemporary medical research

Does Perioperative Lidocaine Infusion Decrease the Mininmum Alveolar Concentration of Isoflurane viz-a-viz Depth of Anaesthesia using Processed Electroencephalogram (Bispectral Index)