English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Treatment of locally advanced head and neck squamous cell carcinoma (LAHNSCC) is a challenging proposition. Prolongation of overall treatment time has shown to increase the failure rates. We aimed to shorten the overall treatment time by using accelerated fractionation-six fractions of radiation per week instead of 5 fractions. Study aimed to assess the response and toxicity profile of six fractions of radiation per week in LAHNSCC. Material and Methods: Stage III and IV LAHNSCC selected for radiation treatment alone with Co60 teletherapy machine. The total dose of 66Gy /33 fractions – 6 fractions per week, from Monday to Saturday over a period of 5.3 weeks. Results: All the 45 patients received the planned treatment. All patients completed the treatment in stipulated overall treatment time. At the 6thweek of completion of radiation, responses were assessed. Out of 45 patients, 29 had the complete response (64.4%), and 12 had the partial response (26.66%), no response seen in 3 patients (6.66%) and progressive disease in 1 patient (2.22%). Patients reviewed twice weekly for assessing the toxicities. Major toxicities were mucosal and dermatological. 38 patients out of 45 had grade I and II skin reactions (83.6%), and 7 patients developed grade III skin reaction(16.4%). 29 out of 45 patients developed grade I and II mucosal reactions(65%) 16 out of 45(35%) patients had grade III mucosal reactions. None of the patients developed grade IV skin or mucosal reactions. Conclusion: This study shows that pure accelerated Radiotherapy 6 fractions per week in LAHNSCC is feasible and found to enhance the response rate with tolerable

Locoregional Control and Toxicity Profile of Six Fractions of Radiotherapy per Week in Locally Advanced Squamous Cell Carcinoma of Head and Neck