English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Conotoxins are a group of cysteine-rich peptide-based toxins in the venom of cone snails. The small peptides of α-Conotoxin Mr1.7a from Conus marmoreus behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor nAChR α3β2. Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels, widely spread in the central and peripheral system. nAChRs modulate the release of neurotransmitters, such as dopamine, norepinephrine, acetylcholine and γ-amino butyric acid, and they are involved in a variety of pathophysiologies, including chronic pain syndromes, epilepsy, Parkinson’s and Alzheimer’s. The physicochemical properties of the α-Conotoxin Mr1.7a were analyzed by using ExPASy ProtParam tool. The secondary structure prediction was done by SOPMA which showed that alpha helix dominated all the other conformations. 3D structure was predicted using modeller and validated using PROCHECK with 83.9 % found in most favoured regions [A, B, L]. VaxiJen 2.0 server predicted αConotoxin Mr1.7a as a non-antigenic. Binding sites were predicted using DoGSiteScorer. Docking of α-Conotoxin Mr1.7a was performed against target neuronal nAChR α3β2 using Hex 6.3 tool. The docking result with Etotal of -598.19 was provided a reasonable structural basis that can be used for future investigations on nAChR-ligand complex and α-Conotoxins serve as a best therapeutic agent.

In silico Characterization and Docking of ?-Conotoxin Mr1.7a from Conus marmoreus Targeting Neuronal nAChR ?3?2