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Acute renal failure ARF is common condition can be categorized as prerenal, intrinsic or postrenal causes in which the glomerular filtration rate decreases GFR over days to weeks . The aim of this study was to test whether the administration of pomegranate and sodium bicarbonate minimize the adverse health effect of acute renal failure. Methods : twenty female rabbits were assessed in to five groups ( n = 4 ) ,Group 1 : control group (C) .Group 2 : Gentamicin group ( G ): animals were injected with a single dose of Gentamicin ( 80 mg / Kg / bw ) intramuscular , daily for 10 days to induce renal failure. Group 3 : sodium bicarbonate group ( G+S ),animals were treated as in group 2 plus they received sodium bicarbonate ( 1 ml / Kg / bw ) of 8.4% by gavage daily for 10 days .Group 4 : pomegranate group ( G+P ),animals were treated as in group 2 plus they received pomegranate 500 ( mg / Kg / bw ) by gavage. Group 5 : combination group ( G+S+P ),animals were treated as in group 2 plus group 3 and group 4 for 10 days. Results : serum creatinine and blood urea levels were decreased in both groups (G+P) and (( G+S+P ) , p < 0.05 . while in group ( G+S ) they increased more effectively than the ( G) group .Serum electrolytes concentrations and serum ( pH ) shows different response , they were improved mostly in the ( G+S+P ) group, and they fluctuated in (G+S) group showing significant decreasing in serum ( Cl and Ca ) , p < 0.05 . Although the results for the hematological parameters were also improved in the combination group ( G+S+P ) but the differences were non significant between all others measured parameters and control group. Conclusions : the administration of sodium bicarbonate in Gentamicin model to induced acute renal failure inducement has adverse biological effects . but those effects were minimized by the ameliorative effects of the pomegranate administration which was helpful in speeding recovery

Protective Role of Pomegranate and Sodium bicarbonate on Acute Renal Failure Induced by Gentamicin In Rabbits Model