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ABSTRAK Alloh menciptakan semua tanaman di dunia ini dengan manfaatnya masing-masing. Delima adalah salah satu tanaman yang memiliki banyak manfaat. Salah satu bagian buah delima yang dapat dimanfaatkan menjadi tablet effervescent adalah kulit buahnya. Salah satu sumber bahan dalam pembuatan tablet effervescent adalah sumber asam. Tujuan dari penelitian ini untuk mendapatkan formulasi tablet effervescent ekstrak kulit buah delima dan pengaruh penggunaan variasi asam sitrat asam tartrat terhadap sifat granul dan sifat fisik tablet. Perbandingan asam sitrat dan asam tartrat yang digunakan adalah Formulasi I (3:2), Formulasi II (2:2), dan Formulasi III (4:3). Metode yang digunakan adalah metode kempa langsung. Evaluasi mutu fisik granul meliputi uji sifat alir, sudut diam, dan indeks pengetapan. Evaluasi mutu fisik tablet effervescent yang meliputi uji keseragaman bobot, uji kekerasan tablet, uji kerapuhan tablet, dan uji waktu larut. Analisis ragam statistik menunjukkan bahwa variasi asam sitrat dan asam tartrat memberikan pengaruh signifikan terhadap sudut diam dan kekerasan tablet, namun tidak berpengaruh signifikan terhadap waktu alir, pengetapan, keseragaman bobot, kerapuhan, dan waktu larut. Formula terbaik berada pada formulasi III (asam sitrat : asam tartrat, 4:3). Kata kunci: Formulasi, Tablet Effervescent, Ekstrak, Kulit Delima, Asam Sitrat, Asam Tartrat ABSTRACT Allah created all the plants in this world with their own benefits. Pomegranate is one of the plants that has many benefits. One part of the pomegranate that can be utilized to be effervescent tablet is the fruit peel. One of the sources ingredients in the formulation of effervescent tablet is the source of acid. This study aims to find the best formula for effervescent tablets of extract leather White Pomegranate and investigating the effect of variation of citric and tartrate acid to characteristic of granule and tablet. The ratio of citric acid and tartare acid used was Formulation I (3: 2), Formulation II (2: 2), and Formulation III (4: 3) . The method used was direct screw press method. The physical quality granule was tested including the flow time, angle of repose, and tap index. The physical quality of the effervescent tablet was tested including uniformity of weight, hardness, friability, and dissolving time. Analysis of the multiform statistics show that variations of citric and tartrate acid gives significant influence towards the angle of repose and hardness of the tablet, but no significant to the time of flow, tap index, uniformity of weight, friability, and dissolving time. The best formula was at the formulation III (citric acid: tartrate acid, 4:3). Key words: Formulations, Effervescent Tablet, Extract, Leather of Pomegranate, Citric Acid, Tartrate Acid

FORMULASI TABLET EFFERVESCENT EKSTRAK KULIT BUAH DELIMA PUTIH (Punica granatum var. album) DENGAN VARIASI ASAM SITRAT DAN ASAM TARTRAT