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ABSTRAK Allah menciptakan segala sesuatu di alam semesta ini untuk diambil manfaatnya, salah satunya adalah tanaman Daun Afrika. Salah satu manfaat daun ini adalah untuk mengobati diabetes mellitus, malaria dan disentri. Daun Afrika mengandung senyawa golongan saponin, flavonoid dan glikosida steroid. Obat yang masuk ke dalam tubuh akan melalui fase metabolisme di hati dan ekskresi di ginjal. Ginjal berfungsi untuk membuang sampah metabolisme dan racun tubuh dalam bentuk urin. Tujuan penelitian ini adalah untuk mengetahui pengaruh infusa Daun Afrika terhadap histopatologi ginjal mencit galur BALB/c. Sampel berupa mencit jantan galur BALB/c sebanyak 12 ekor dibagi dalam 4 kelompok perlakuan yaitu kontrol (aquades), infusa Daun Afrika 10% b/v, 20% b/v dan 30% b/v yang diberikan secara peroral selama 28 hari. Data dianalisa dengan uji Kruskall Wallis dan menunjukkan nilai kongesti 0,241 > p 0,05 dan nilai hemorragi 0,070 > p 0,05 yang berarti tidak terdapat perbedaan yang nyata antar kelompok perlakuan. Oleh karena itu, dapat disimpulkan bahwa pemberian infusa Daun Afrika tidak berpengaruh terhadap histopatologi ginjal mencit galur BALB/c. Meskipun demikian, kecenderungan hasil dalam penelitian ini menunjukkan bahwa peningkatan dosis yang diberikan kepada mencit dapat mengurangi kongesti dan hemorragi pada ginjal. Kata kunci: Uji Toksisitas, Infusa, Daun Afrika, Histopatologi Ginjal ABSTRACT Alloh created everything in this universe to take benefit from it , including African Leaf plant. One of the benefits of this leaf is to treat diabetes mellitus, malaria and dysentery . African lea f contains saponin type compounds, flavonoids and steroid glycosides. Drugs that enter the body will go through the phase of metabolism in the liver and excretion in the kidneys. Kidney that serves to dispose of metabolic waste and body toxins in the form of urine. The purpose of this research is to know the effect of African Leaf infus ion on histopathology of mice kidney BALB/c. Samples in the form of BALB / c male strain of mice were 12 samples were divided into 4 treatment types with 3 replications. Treatment of control (aquades), African leaf infusion 10% b /v, 20% b /v and 30% b /v infused orally for 28 days. The data obtained were analyzed by Kruskall Wallis test and t he data shows congestion value 0.241 > p 0.05 and hemorragi c value 0.070 > p 0.05 which means there is no significant difference between treatment types . Therefore, it can be concluded that African leaf infusion has no effect on histopathology of renal mice BALB/c. However, the trend of results in this study indicates that the increased dose given to mice can reduce congestion and hemorrhage in the kidneys. Keywords: Toxicity Test, Infus e , African Leaves, Kidney Histopathology

UJI TOKSISITAS SUB AKUT INFUSA DAUN AFRIKA (Vernonina amygdalina Del.) TERHADAP HISTOPATOLOGI GINJAL MENCIT GALUR BALB/C