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One of the efforts to prevent crop failure in vanname shrimp (Litopenaeus vannamei) can be done by increasing immunity in vanname shrimp. Increased shrimp immunity by chemical means has a weakness that can create resistance to bacteria. To overcome the positive impact of the use of antibiotics in preventing infection in vanname shrimp by utilizing a natural ingredient with medicinal properties namely kasembukan (Paederi foetida Linn.) The research aims to determine the immunity of vanname shrimp and survival ratio. The  research used a Completely Randomized Design with the treatment of paederia leaf concentration added to commercial shrimp feed, namely A1; A2; A3; A4; A5 (0%; 10%; 20%; 40%; 80%). Observations were made on day 0, day 10, day 20 and day 30. The results of research using ANOVA showed that there was an effect of treatment on immune vanname shrimp based on total vanname shrimp hemocytes. Dunconu0027s further tests showed that the treatment of adding 10% and 20% of the paederia leaves had the same effect while the addition of 0%, 40% and 80% of the paederia leaves had a reduced effect on the total haemocyte of vanname shrimp. The survival ratio (SR) of vanname shrimp for each treatment for 30 days were A1: 80%, A2: 100%, A3: 90%, A4: 91% and A5: 96%.    Keywords:   Immunity, feed, Litopenaus vannamei, Paederia foetida L.    ABSTRAK    Upaya dalam mencegah kegagalan panen pada budidaya udang vanname (Litopenaeus vannamei) salah satunya dapat dilakukan dengan cara meningkatkan i  muni  tas pada udang vanname. Peningkatan imunitas udang dengan cara kimia memiliki kelemahan yaitu dapat membuat resistensi pada bakteri. Untuk menanggulangi dampak positif penggunaan antibiotik dalam mencegah infeksi pada udang vanname yaitu dengan cara memanfaatkan bahan alami berkasiat obat yaitu kasembukan (Paederi foetida Linn.) Penelitian bertujuan untuk mengetahui imunitas udang vanname serta kelulus hidupan udang yang diberi pakan tambahan daun ksembukan sebagai imunostimulan. Rancangan penelitian menggunakan Rancangan Acak Lengkap dengan perlakuan konsentrasi tepung daun kasembukan yang ditambahkann pada pakan udang komersil yaitu A1; A2; A3; A4; A5 (0%; 10%; 20%; 40%; 80%). Pengamatan dilakukan pada hari ke 0, hari ke 10, hari ke 20 dan hari ke 30. Hasil penelitian menggunakan ANOVA menunjukkan terdapat pengaruh perlakuan terhadap imun udang vanname berdasarkan total hemosit udang vanname. Uji lanjut Duncon menunjukkan bahwa perlakuan penambahan 10% dan 20% daun kasembukan memiliki pengaruh yang sama sedangkan penambahan 0%, 40% dan 80% daun kasembukan memiliki pengaruh yang bereda terhadap total hemosit udang vanname. Kelulus kehidupan udang vanname untuk masing-masing perlakuan selama 30 hari yaitu A1:80%, A2:100%, A3:90%, A4:91% dan A5:96%.   Kata Kunci:   Imunitas, kasembukan, pakan, udang vanname

IMUNITAS UDANG VANNAME (Litopenaeus vannamei) YANG DIBERI PAKAN TAMBAHAN DAUN KASEMBUKAN (Paederia foetida Linn.)