English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Photox has been identified as an ADP-ribosylating toxin, produced by Photorhabdus luminescens, which targets actin. Recent unpublished studies have suggested that Photox may also target actin-related proteins (Arps). Herein we report possible interacting residues of actin, Arp1 and Arp2, with Photox. Both actin and Arp1 were predicted to interact with Photox in six main groups across the NAD+ binding surface whereas four interaction groups were proposed between Arp2 and Photox. The possible interactions evaluated included hydrogen bonds, salt bridges, and electrostatic and hydrophobic interactions. Our results suggest that Arp1 is a very likely target of Photox, while Arp2 is also a possible candidate; however, the possible interactions between Photox and Arp2 appear to be weaker than the possible interactions between Photox and Arp1. Understanding the various interactions of Photox and its targets may help to provide insight into its biological action, and may potentially lead to a treatment plan for similar toxin-related diseases.  Keywords: ADP-ribosylating toxins; Photox (Photorhabdus luminescens); actin-related proteins (Arp1, Arp2) (targeting of); in silico modeling of protein interactions

In silico modeling of Arp1 and Arp2 as targets of Photox ADP-ribosylation