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Nasopharyngeal carcinoma (NPC) is a common malignant head and neck tumor, which is particularly prevalent in East and Southeast Asia. NPC is characterized by aggressive cellular behaviors such as early lymphatic spread and a strong predisposition to the formation of distant metastases (1). In recent years, with the improvement of the diagnosis and treatment of NPC, the incidence and mortality of NPC are gradually decreasing (2), but the prevalence of distant metastasis among patients with NPC is still as high as 14.1% (3). Thus, a great clinical need exists for the development of improved, individualized methods for the diagnosis and treatment of NPC. Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase, which has attracted widespread attention from Original Article

shRNA targeting PLK1 inhibits the proliferation and invasion of nasopharyngeal carcinoma cells