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Malignant tumors are one of the main threats to national public health and the second most common cause of death. It is expected that there will be more than 20 million new cases of malignant tumors in 2025 (1). Among all malignant tumors, squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common malignant tumor worldwide and includes oral squamous cell carcinoma (OSCC) (2,3). In 2012, the mortality rate of 145,000 patients with OSCC was approximately Original Article

Bioinformatics analysis reveals that ANXA1 and SPINK5 are novel tumor suppressor genes in patients with oral squamous cell carcinoma