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The incidence of esophageal adenocarcinoma (EAC) has increased (1), with gastroesophageal reflux thought to be a major contributor to the occurrence of EAC and high grade dysplasia (HGD). Barrett’s esophagus (BE) is one of the steps in which adverse events occur and is characterized by the squamous epithelium of the lower part of the esophagus being covered by the columnar epithelium. Gastric acid can be reduced by proton pump inhibitors (PPIs), which then can slow the BE process. At present, PPIs are recommended for the treatment of BE, but the evidence concerning PPIs’ use to prevent the progression from BE to HGD and EAC seems to be insufficient. Several studies have reported that using PPIs may decrease the risk of HGD and EAC (2,3). Original Article

translational cancer research

Risk of esophageal adenocarcinoma in patients with Barrett’s esophagus using proton pump inhibitors: a systematic review with meta-analysis and sequential trial analysis