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Colorectal cancer (CRC) is one of the most common malignant tumors in the world, and liver metastasis is the most common form of CRC metastasis (1). Studies have shown that liver metastasis can occur in ~20% of newly diagnosed CRC patients within half a year (2,3). In addition, >50% of patients with advanced CRC have a median survival of only 21.3 months (4). Currently, the “seed and soil” theory proposed by British surgeon Dr. Stephen Paget is generally accepted as the underlying developmental mechanism of colorectal cancer liver metastases (CRLM) (5). On this basis, the “cancer stem cell theory” has been expanded in recent years (6). Cancer stem cells (CSCs) are a group of tumor cells that are self-sustaining and possess the ability to differentiate into different types of cells. CSCs are the source of the Original Article

Effect of hematopoietic progenitor cells on the biological characteristics of colon cancer tumor stem cells