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Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, China; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan; School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Department of Biology, Faculty of Science, Mahasarakham University, Mahasarakham, Thailand; School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China Contributions: (I) Conception and design: M Jinushi, Z Xu; (II) Administrative support: M Jinushi, Z Xu; (III) Provision of study materials or patients: M Jinushi, T Yaguchi, Y Kawakami; (IV) Collection and assembly of data: M Jinushi, Z Xu, B Wang, T Yaguchi; (V) Data analysis and interpretation: M Jinushi, Z Xu, B Wang, T Yaguchi; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Zhifang Xu, PhD. School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, No. 10 Poyang Lake Road, Tuanbo New Town, Jinghai District, Tianjin 301617, China. Email: xuzhifangmsn@hotmail.com; Masahisa Jinushi, PhD. Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. Email: mjinushi0412@gmail.com.

translational cancer research

Combinatorial sympathetic and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockades inhibit the murine melanoma growth by targeting infiltrating T cells