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Lung cancer accounts for approximately 13% of newly diagnosed cancers worldwide and is the leading cause of cancer-related deaths (1). Approximately 85% of all lung cancers are non-small cell lung cancer, and lung adenocarcinoma is the main tissue subtype, accounting for more than 50% of all non-small cell lung cancers (2). More than 70% of patients with non-small cell lung cancer have locally advanced or distantly metastatic disease at the time of diagnosis (3); however, platinumOriginal Article

Application of CT radiomics features to predict the EGFR mutation status and therapeutic sensitivity to TKIs of advanced lung adenocarcinoma