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According to the World Cancer Report 2014, gastric cancer (GC) has the fifth leading incidence of cancers and is the third leading cause of death from cancer. Approximately 951,600 new GC cases were diagnosed and 723,100 GCrelated deaths occurred in 2012 (1). Hence, GC is currently a significant public health issue in the world. Although the GC incidence and mortality rates are generally declining in many countries, GC survivors still account for a large proportion of all cancer patients (2,3). With the large population of GC survivors, one concerning issue is their long-term survival status, especially the risk of developing second primary malignancies (SPMs) (4,5). Previous studies have reported that the risk of developing an SPM is increased in several types of cancer (6-8). Accumulating evidence has suggested that healthy aging, intensive treatment of the primary tumor, and genetic and Original Article

Incidence features of second primary malignancy among gastric cancer survivors, 1992–2012