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OS, the most common malignant bone tumor, posing great impact on the health of children and adolescents (1,2). Although survival rate of OS patients was improved after the improvement of combined chemotherapy and surgery, fatal metastasis was still a significant factor in reducing survival rate of OS patients (3). Currently, the underlying mechanism of OS are still not completely clarified. Furthermore, there is no effective method to monitor OS metastases early. Therefore, it is imperative to find the robust prognostic biomarkers of metastatic OS (4,5). Active intervention and treatment can be applied to those patients with a higher risk after initial diagnosis to improve their prognosis, according to high expression of certain biomarkers. So far, positive expression of Livin has been considered as a OS prognosis-related biomarkers (6). Many studies have recently revealed that the development of OS is strongly linked to apoptosis of cell (7-9), and the over-expression of apoptosis-related protein Livin is strongly Original Article

Prognostic value of Livin in surgical specimen and biopsy in patients with osteosarcoma