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Although cigarette smoking is a risk factor for multiple disorders, it has long been thought to protect against Parkinson's disease (PD). Quantitative susceptibility mapping (QSM) is a novel magnetic resonance imaging (MRI)-based technique for assessing iron accumulation in vivo that has been widely applied in PD studies. This study aimed to investigate how cigarette smoking affects clinical performance of PD using quantified iron deposition as a proxy for PD pathology.

quantitative imaging in medicine and surgery

The protective role of cigarette smoking against Parkinson’s disease via moderation of the interaction between iron deposition in the nigrostriatal pathway and clinical symptoms