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Ventilatory inefficiency contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). The intercept of the minute ventilation (V ˙  E ) vs. carbon dioxide output (V ˙ CO 2 ) plot is a key ventilatory inefficiency parameter. However, its relationships with lung hyperinflation (LH) and airflow limitation are not known. This study aimed to evaluate correlations between the V ˙  E /V ˙ CO 2 intercept and LH and airflow limitation to determine its physiological interpretation as an index of functional impairment in COPD.

journal of thoracic disease

Intercept of minute ventilation versus carbon dioxide output relationship as an index of ventilatory inefficiency in chronic obstructive pulmonary disease