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BRAF V600E  mutations occur in fewer than 10% of all patients with metastatic colorectal cancer (CRC) and arise from sessile serrated adenomas. Despite efficacy with targeted therapies against MAPK signaling and with immunotherapies in this population, survival outcomes for patients with BRAF V600E  mutated metastatic CRC in general are poor. Characteristics distinguishing patients with BRAF V600E  mutated metastatic CRC with favorable versus unfavorable outcomes have not been well annotated.

Clinical and pathologic features correlated with rare favorable survival in patients with BRAFV600E mutated colorectal cancer