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Colon cancer is currently the third most common cancer and cause of cancer-related deaths in the United States. Approximately 35–55% of patients with colorectal cancer present with metastatic disease; of these, 10–20% of patients have resectable disease, with the liver being the most common site of metastasis (1). Surgical resection is considered the gold standard curative option for metastatic disease, with overall 5-yr survival of 35–55% after successful resection (1). Many patients with surgically unresectable disease, however, are candidates for microwave (MW) or radiofrequency ablation (RFA) of hepatic metastases or other liver-directed therapies. While ablation can often be performed minimally invasively or percutaneously and is generally well tolerated with effective local tumor control, it is not without limitations.

Could hepatic ablation promote development of colon cancer hepatic metastases?