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Sesquiterpenoid is a class of terpenoid compounds that have the most abundant diversity of structures  and  biological activit ies that can be found in natural  resource s.  T ropical plants are main source of sesquiterpenoid compounds such as  Aglaia genus belong to M eliaceae family.  A. harmsiana is a species from  Aglaia that only has few previous researchs.   Therefore, the purpose of this study was to isolate and determine the structure of sesquiterpenoid compounds from stem bark A. harmsiana along with their cytotoxic activity against MCF-7 breast cancer cells. The isolation process begins by extracting powder from  A. harmsiana stem bark using  n -hexane, ethyl acetate and methanol.  All extracts were evaluated for their cytotoxic activity against  MCF-7 breast cancer cells, and  n -hexane extract s showed significant cytotoxic activity with  IC 50 values of  117.86 µg/mL. Therefore,  n -hexane extracts were  further  separated and purified by various chromatographic  techniques to obtain compounds  1 and  2 . Compounds  1 and  2 were elucidated  their chemical structures  by spectroscopic methods  including IR, NMR, and MS  as well as by comparison of data with literatures  and identified as caryophyllene -type sesquiterpenoid s ,  β - caryophyllene oxide ( 1 ) and senecrassidiol ( 2 ). Compounds  1 and  2 were submitted for cytotoxic eveluation on MCF-7 breast cancer cells and as a result,  β -caryophyl l ene oxide ( 1 ) showed the stronger activity  compared to  senecrassidiol ( 2 ). These finding  indicated that the cytotoxic activity of  caryophyllene -type sesquiterpenoid  are influenced by the presence of double bonds and configuration of methyl groups.

Caryophyllene-Type Sesquiterpenoids from the Stembark of Aglalia harmsiana and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells