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P impinella pruatjan  Molk is a local indegineuos plant speciescommonly used   aphrodisiac . This study was  performed  to analyze the effect of acute administration of  purwoceng ( P impinella pruatjan  Molk .)  roots ethanol extract to liver and kidney histological damage in  r ats. The study used  an experimental app roach using post test only with control group design. Rats were randomly divided into five groups; 3 rats in each group. Group A as a control group received aquadest, group B, C, D, and E were given purwoceng roots ethanol extract dose of 5 mg/kgBW, 50 mg/kgBW, 300 mg/kgBW, and 2000 mg/kgBW respectively.Liver histological damage was assessed by a modification of the Roenigk score, wher eas kidney damage  was by the  semiquantitative scoring of proximal tubular necrosis. UV test was used to qu antify the  AST and ALT levels,  the measurement of  blood urea levels  was using the  Urease-GLDH method , and  Jaffe method was used  to access the creatinine levels.Kruskal-Wallis test showed that liver and kidney histological parameters were not significantly affected, as well  as the blood urea and creatinine levels (p>0.05). Meanwhile , ALT  level  was only parameters which showed the  significant  test ( p <0.05 ) among groups.  Study concluded that the l iver and kidney histological appearance, AST, blood urea, and creatinine levels in the male albino rat were not significantly affected by acute administration of Purwoceng roots in various doses but   the ALT level was significantly affected

molekul

No Acute Toxicity Tests of Purwoceng (Pimpinella pruatjan Molk.) Ethanolic Extract on Male Albino Rat by Determined Hepatorenal Function Test and Histopathology