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In the present era, cancer remains a major global health concern, being one of the world’s most deadly diseases. Despite significant breakthroughs in the understanding, prevention, and treatment of this disorder, cancer is still the point of concern for the whole world. In 2018 nearly 18.1 million people around the world had cancer and 9.6 million died from the disease. This number will nearly double by 2040, with almost two thirds increase to occur in low and middle income countries (WHO, 2020). Portulaca oleracea (commonly known as Nunner in Kashmir) is an underutilized wild vegetable in the Kashmir region. This vegetable is believed to be highly nutritional and quite health beneficial, however, has remained highly unexplored. Therefore, in the current study, the nutraceutical composition as well as antimicrobial and anticancerous potential of wild edible herb Portulaca oleracea (common purslane) was determined in its fresh as well as dried form. The results revealed that dried form comparatively contains higher carbohydrates (25.1±0.173%), crude protein (19.83±0.145%), crude fat (4.02±0.011%), crude fiber (7.19±0.017%), total soluble sugars (3.56±0.012%), reducing sugars (3.16±0.012%) and non-reducing sugars (0.40±0.023%). In addition, Portulacaoleracea proved to be a rich source of calcium (1366.66±0.120mg/100g), magnesium (943.93±0.713mg/100g), sodium (153.63±0.145mg /100g) and iron (47.66±0.088mg/100g) content. The nutraceuticals were also found to be present in appreciable amounts includingtotal phenols 385.96±0.744mg/100g, total flavonoids 98.66±0.120mg/100g and total anthocyanins 881.76±0.088mg/100g, respectively. The antimicrobial assay demonstrated that P. oleracea has great potential to be used as an antimicrobial agent against Staphylococcus aureus and E. coli (EPEC) pathogens. Interestingly, the aqueous extracts of dried P. oleracea exhibited potent dose and time dependent cytotoxic effects against HL-60, MOLT-4 and T47-d cancer cell lines under in vitro conditions. Thus, through this study, we provide a scientific basis for nutraceutical rich Portulaca oleracea from Kashmir valley for its folklore or ethno-medicinal uses, and for its further exploitation as a highly useful alternative strategy for antimicrobial and anti-cancer drug development or as an adjuvant to existing therapies. K e y w o r d s

Anti-cancer and Anti-microbial Potential of Nutraceutical Rich Under utilized Herb Portulaca Oleracea from Kashmir Region