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Keratoconjunctivitis sicca (KCS), also known as dry eye syndrome, is a chronic ophthalmic disease resulting from deficiency of proteins/cytokines in the pre-corneal tear film (Berdoulay et al., 2005). There are different stages of the KCS like early, late and ulcerative or it can also be categorized as the mild, moderate and severe KCS (John et al., 2018). Clinically, KCS manifests as mucoid ocular discharge, conjunctival hyperemia, blepharospasm, recurrent corneal ulceration, corneal vascularisation, fibrosis, and eventual pigmentation (Berdoulay et al., 2005).

Effect of Tacrolimus Treatment on Tear Fluid Cytokines of Keratoconjunctivitis SICCA Affected Dogs