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Head and neck squamous cell carcinoma (HNSCC) is the 6th most frequently diagnosed malignancy and accounts for about 5% of all malignancies worldwide. There is a lack of biomarkers to monitor the status and progress of the disease. Therefore, it is of great importance to develop non-invasive diagnostic tools such as exosomes that monitor tumor changes and provide molecular information about the malignancy to identify the metastatic disease earlier and allow better therapeutic management. Thus, we aimed to review whether tumor-derived exosomes can predict disease progression in HNSCC and if and especially how they can be used as a diagnostic tool.

Exosomes as a promising diagnostic tool in head and neck squamous cell carcinoma?