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ADPKD is associated with large interfamilial and intrafamilial variability [1]. Many scientists studied the mechanism [2-5] of the ADPKD and its treatment from various methods [6-8]. Form the genome perspective, there are two mutations have been found to be associated with adpkdPKD1 and PKD2 [9-12]. They are respectively on the 16th and 4th chromosomes [13-15]. Most of the ADPKD are caused by PKD1 mutation. Most of the patients with ADPKD may require dialysis or kidney transplantation eventually [16-18]. Therefore, it is necessary to study the ADPKD from the perspective of genome. Many scientists such as Tao Yang, et al, explored the novel mutations of PKD1 gene in Chinese patients with ADPKD by targeted nextgeneration sequencing [19], Consugar, et al. studied the characteristics of large rearrangements in ADPKD and the PKD1/TSC2 contiguous gene syndrome [20]. Furthermore, Pathogenicity [21], inactivation [22], development [23] of the PKD1 were also studied by many scientists. In this paper, based on the previous studies, the codon usage characteristics of PKD1 and PKD2 gene is cauculated via the CodonW, and analyzed via the PR2-bias plot analysis: A3 / (A3 + T3) vs. G3 / (G3 + C3) . Then the RSCU values of PKD1 and PKD2 are plotted and discussed.

Codon Usage of Autosomal Dominant Polycystic Kidney Disease Genes PKD1 and PKD2