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This study was carried out to investigate the effect of nanoparticles of olive (Olea europaea L.) seeds and its powder on obese hyperlipidemic rats. Methods: Cellulose of olive seeds were isolated by 15% NaoH at 160∘ C for two hours, according to (Wise et al., 1946).Cellulose Nanocrystals (CNC) were isolated from olive seeds bleached pulp by acid hydrolysis using 65% sulphuric acid at 45°C for 45 minutes as previously described (Hassan et al., 2014). Thirty (30) male albino rats of Sprague Dawley strain divided into six groups. Group(1) fed on the basal diet (negative control), (2)fed on the hyperlipidemic diet (HD) (positive control), (3) fed on HD + 2% nanoparticles from olive seeds (NOS), (4) fed on HD +4% NOS, (5) fed on HD +5% olive seeds powder (OSP), (6) fed on HD +10% OSP. Total Phenolic Compounds ,Concentration Phenolic Compounds, (SEM) examination, food intake, body weight gain ratio, lipids profile (Total lipids TL, Triglycerides TG, Total cholesterol TC, LDL, HDL & VLDL ) , liver functions (AST, & ALT) , Total protein , albiumine , were determined. Results: The results observed that, the body weight gain ratio (BWG%), had significantly decrease (P≤ 0.05) in all groups G3: G6 which fed on hyperlipidemic diet supplemented by different levels of NOS or OSP, with mean values of ( -28.85±2.51 g, -41.26±5.51 g, -12.57±3.30 g and -20.31 ±5.39 g, respectively) when compared with the positive control group which fed on hyperlipidemic diet without supplementation (13.73±1.91g). Moreover, rats treatment with nanocellulose from olive seeds (NOS 2%& 4%) had significantly decrease in lipids profile levels (TL, TG, TC, LDL & VLDL), Liver function when compared with the positive control rats . Also, The lowest value in total cholesterol was recorded with group administrated with nanocellulose from olive seeds (NOS 2%& 4%) 73.15 d ±4.06 & 73.42 d ±5.26 respectively when compared with negative and positive control groups with a mean value of 64.99 e ±2.90 and 178.38 a ±5.69 respectively . In addition, The lowest value in triglycerides was recorded with group administrated with nanocellulose from olive seeds (NGS 4%) 88.82 e ±3.91 compared with negative and positive control groups with a mean value of 87.2 d ±4.02 and 345.32 a ±4.21 respectively . In addition, it revealed that rats were fed on hyperlipidemic diet supplemented with olive seeds powder OSP by different levels 5% & 10% and nanoparticles of olive seeds NOS2% had significant decrease in the serum AST and ALT when compared with the positive control group except in group (4) which rats fed on hypercholesterolemic diet supplemented with NGS 4%. Also, the lowest reduction value of AST were found in group (6) when rats fed on hypercholesterolemic diet supplemented with GSP 10% and ALT were found in group (5)when rats fed on hypercholesterolemic diet supplemented with GSP 5% 120.72 c ±10.64 & 57.72 c ±4.41U/L respectively . Conclusions: It can be concluded that nanoparticles isolated from olive seeds had a significant positive effects against obesity and Hyperlipidemic than the effects of olive seeds Powder. Hence, the study may be repeated on patients with hyperlipidemia for possible beneficial effect on humans.

The Impact of Olive Seeds (Olea europaea L.) Powder (OSP) and its Nanoparticles (NOS) on Obese Hyperlipidemic Rats