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Outbreaks of infectious diseases caused by different pathogenic bacteria and fungi and the development of antimicrobial resistance have led to the search for new antimicrobial agentes [1]. A literature review demonstrated remarkable bactericidal, fungicidal and antiviral activity of silver NPs [2]. The chemical and physical methods currently used for the synthesis of NPs are expensive, require high temperatures and high pressures, and produce hazardous wastes that posses risk to the environment [3]. In this respect, biological methods for the nanomaterials synthesis are used worldwide to create nano-factories [4], particularly for the preparation of silver NPs that offer several benefits such as compatibility for pharmaceutical and biomedical application [5]. Yeasts have become important in nanotechnology as producers of NPs, due to their advantages such as low-cost, rapid growth and easy preparation and biomass handling. Salvadori et al. [6] described for the first time the efficient and low-cost synthesis of Ag/Ag2O NPs using dead biomass of the yeast R. mucilaginosa, isolated from the weastewater of a mine in the Amazon region, for nanobioremediation of silver waste and its reuse in NPs form.

Antimicrobial Activity of Ag/Ag2O Nanoparticles Synthesized by Dead Biomass of Yeast and their Biocompatibility with Mammalian Cell Lines