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The popularity of Morinda Citrifolia Linn (Noni) as a dietary supplement, a food functional ingredient, or as a natural health enhancer is increasing throughout the world. Our study aims to investigate the concentrations of 10% and 50% of Morinda Citifolia Linn and usage time and its renal and hepatic toxicity. To this purpose, 42 male wistar rats were distributed into groups: treated for 15 days with concentration of 10% and 50and treated for 90 days with concentration of 10% and 50%. Noni juice has been prepared with fruit’s pulp and seeds at concentrations of 10% and 50% diluted in water. The groups 15 and 90 days presented elevated creatinine, urea, AST and ALT, compared to respectively control groups (p<0,05), and the levels of these markers are higher in 90 days groups.The presence of steatosis and dermatological changes was observed in rats in 90-days and concentration 50%. The fruit juice of Morinda Citrifolia Linn at concentration of 50% causes damage to liver and kidney function, being able to induce development of non-alcoholic liver disease, regardless of usage time. The alterations of hepatic and renal markers are directly proportional to usage time and dose-concentration.

Preclinical Study of Morinda Citrifolia Linn Concentration and Usage Time and its Liver and Renal Toxicity