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Resumo The microorganisms resulting from a pulp infection produce toxic products that are responsible for the persistence and development of endodontic apical periodontitis, with the most recurrent bacterium, Enterococcus faecalis and yeast Candida albicans. Thus, the search for new pharmacological approaches is necessary so that the intracanal medicine associated with mechanical cleaning is able to totally eliminate these pathogens. Chalcone is a flavonoid that has antimicrobial properties and has become the target of studies for antibacterial and antifungal activity.The objective of this project was the bioprospection of aminochalcones against C. albicans and E. faecalis planktonic, as well as biofilms of C. albicans and E. faecalis (mono and mixed), human gingival fibroblast (FGH) toxicity (in vitro) and in Galleria mellonella (in vivo) of chalcona with better activity.

Antimicrobial activity of synthetic chalcone-derived molecules in mixed biofilms and in vitro and in vivo toxicity