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Resumo Denture Stomatitis (DE) is a multifactorial inflammation of the region of the buccal mucosa associated with the use of total dentures that causes pain, burning and discomfort to the patient. When triggered by Candida spp. infection, the symptoms of the clinical condition are prolonged and aggravated. Candida spp is a dimorphic fungus that lives in symbiosis in the human microbiota and that due to changes in the environment may trigger pathological situations such as that cited. Aminochalcone is a flavonoid that has anti-inflammatory, antipyretic and analgesic properties and which, due to the development of resistance to conventional antimicrobials, has become the target of studies for antibacterial and antifungal activity. The objective of this project was the bioprospection of aminochalcones against C. albicans and C tropicalis planktonic, as well as biofilms of C. albicans and C. tropicalis (mono and mixed), human gingival fibroblast (FGH) toxicity (in vitro) and in Galleria mellonella (in vivo) of chalcona with better activity.

Bioprospecting of chalcones against mixed biofilm of Candida albicans and Candida tropicalis