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The role of angiotensin II (AII) on lipolytic metabolism is still controversial in the literature. Diversely, noradrenaline (NOR) is an important stimulator of lipolysis and glycolysis in adipocytes. Spontaneously hypertensive rats (SHR) have lower body weight and smaller adipocytes when compared to its control, Wistar-Kyoto, with higher basal lactate production by area and volume. We aimed in this work to evaluate the influence in downstream cascate of AII and NOR, co-incubated or not, in the production of glycerol and lactate in three different strains. The combination of NOR and AII potentiated the lipolytic activity by decreasing the glucose metabolism to lactate. This effect may be associated with the NOR activity on adrenergic receptors or by the AII activity blockade at AT1 receptors, highlighting the antilipolytic activity of this receptor and the crosstalk between downstream cascade induced by these agonists.

Signaling downstream cascade crosstalk induced by noradrenaline on angiotensin II metabolic activity in adipocytes