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In this crossover, randomized, double-blind study, 20 male volunteers were submitted to topical application of microneedles or flat patches on palatal mucosa, bilaterally in the canine region followed by topical anesthesia procedure with EMLA® (Eutectic mixture of lidocaine and prilocaine) during 2 or 5 minutes. Immediately after, an infiltrative anesthesia was performed by using a 30-gauge short needle and 0.3 mL of lidocaine 2% with epinephrine 1:100,000. Pain sensation during needle insertion and local anesthetic injection was evaluated by using 2 different visual analogical scale (VAS). VAS (in mm) results The use of microneedle as a pretreatment of palatal mucosa did not increase topical anesthetic efficacy of EMLA in reducing pain during needle insertion or local anesthetic injection after 2 min of topical application. However the efficacy of EMLA after 5 minutes of application resulted in reduction of pain during needle insertion, but not to local anesthetic injection (p>0.05).

Topical anesthetic efficacy on palatal mucosa pretreated with microneedles