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In 2007, a high-profile meta-analysis raised concerns about the safety of rosiglitazone, a thenpopular oral hypoglycemic agent. In this study, the authors describe how physicians accessed, evaluated, and applied this information clinically. Their findings showed that although a highly publicized meta-analysis raised concerns among physicians, meta-analyses can be challenging to interpret. Efforts are needed to improve the understanding of this methodology to aid physicians in translating results into practice.

Physicians' Appraisal and Response to Early Evidence on Cardiovascular Risk Associated with Rosiglitazone: Knowledge Translation in Clinical Practice