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Non-union of fractures is conditions, happened due to infection, poor Nutrition or other underlined multiple disorders. Nonunion of fracture bone more than 6 months is consider as chronic one & unhealthy. Platelet rich Plasma is cocktail of various growth factors including VEGF, EGF, PDGF, FGF, IGF. All these factors play role in healing of nonunion fractures. in this Case We reported that Percutaneously Injected Activated PRP at the site of nonunion of fracture help in union of fracture site. We noted its promising case of PRP gel application in Nonunion.

A Case Study of Non- Union of Right Second Metatarsal Bone by Using Activated Platelet Rich Plasma Gel