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The majority of patients with substance use disorders have high grade of depression, suicide and anxiety [1-3]. Moreover, they could have minor psychopathology [4,5] and also personality disorders[6,7]. It should be emphasized that primary psychiatric symptomatology can predict the rate of failure or success in detoxification treatment of substance dependents [8]. Mood disorders could intervene with the course and prognosis of substance dependence. Furthermore, studies indicated that opioid dependent patients having a depressed mood at the beginning of therapy may be less likely to be clean at follow-up than those with a normal mood [9]. Some of the drugs or substances like ketamine, buprenorphine or Ayahuasca, can lower the level of depression and also raise and expand the mood state [10,11].

Buprenorphine in the Treatment of Severe Major Depression with Severe Suicidal Temptations