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Content of nitrogen oxide synthases in the mucosa of the stomach and duodenum of patients with NSAID gastropathy. The article presents results of immune histochemical investigation of the levels of inducible and endothelial nitric oxide synthases (iNOS and eNOS) in 120 patients with gastroduodenal inflammatory and erosive lesions of against the long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), and in 20 subjects without endoscopically verified gastrointestinal pathology, who comprised control group. The mean iNOS levels in patients with NSAIDs-gastropathies was (2,30 ± 0,09) and (2,39 ± 0,07) in patients of the first and second groups, in the control group – (0,20 ± 0,09) c.u; eNOS – (2,10 ± 0,09) and (2,02 ± 0,09) c.u. respectively, in the control group (0,65 ± 0,11). The direct correlation has been established between the levels of iNOS, eNOS and lesions of gastroduodenal mucosa at NSAID gastropathies (p < 0,001). These figures indicate the direct role of nitric oxide synthases in the chain of pathological reactions that develop in the stomach and duodenum of patients with NSAIDs – gastropathies.